- Description
- Product Info
- Shipping and Storage
- Downloads
- References
Description
Ribavirin is a purine nucleoside derivative that exhibits antiviral and anti-inflammatory activities. This compound displays broad spectrum antiviral activity but is most often clinically used in conjunction with IFN to treat hepatitis C infection. In macrophages, ribavirin decreases NO levels.
Product Info
36791-04-5 |
≥98% |
C8H12N4O5 |
244.21 |
1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide |
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide |
Copegus; Ribamidil; RTCA; Varazid; Virazole |
166-168°C |
Soluble in water. |
White Crystal Powder |
Shipping and Storage
4°C |
Ambient |
Downloads
R3205 Info Sheet PDF |
References
Pinilla-Macua I, Fernández-Calotti P, Pérez-Del-Pulgar S, et al. Ribavirin Uptake into Human Hepatocyte HHL5 Cells Is Enhanced by Interferon-α via up-Regulation of the Human Concentrative Nucleoside Transporter (hCNT2). Mol Pharm. 2014 Sep 2;11(9):3223-30. PMID: 24957263.
Parekh PJ, Shiffman ML. The role of interferon in the new era of hepatitis C treatments. Expert Rev Gastroenterol Hepatol. 2014 Aug;8(6):649-56. PMID: 24758387.
Wohl BM, Smith AA, Kryger MB, et al. Narrow therapeutic window of ribavirin as an inhibitor of nitric oxide synthesis is broadened by macromolecular prodrugs. Biomacromolecules. 2013 Nov 11;14(11):3916-26. PMID: 24156371.
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